Sergi Roberto will have surgery on his thigh injury.
The Spanish defender made around 12 appearances this season but is yet to feature for new boss Xavi.
His injury will leave him out of action for nearly three to four months and will likely play again this season.
Roberto will enter the final six months of his contract in January and is yet to agree to a fresh new deal.
The news is a huge blow to his future prospects of staying at Camp Nou beyond this season.
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A club statement read: “The first team player Sergi Roberto will be under surgery in the coming days for the injury he sustained to his rectus femoris muscle in his right thigh.
“The procedure will be carried out by Dr. Lasse Lempainen in Turku, Finland under the supervision of the club’s medical staff. When the surgery has been carried out, the club will issue a new press release.”