The two global stars are expected to face in the Champions League next week.
One of the greatest rivalries in world football, Lionel Messi hopes Ronaldo can take part in the Champions League clash between Barcelona and Juventus.
Ronaldo tested positive for the coronavirus on October 13 and is still under self-isolation.
His participation in this nerve-wracking fixture is looking more unlikely now and Messi would really want him to play some part in the game.
‘Obviously when Cristiano played for Real Madrid the games were special,’ Messi told DAZN ahead of this weekend’s Clasico.
‘Matches against them always are [special], but with Cristiano on the pitch they took on a particular significance.
‘That is now in the past and we look forward to today’s challenges. Wednesday there could be this challenge and we hope Cristiano can be there and will soon recover from Covid.’
On his Clasico meetings with Ronaldo, Messi added: ‘The ones with Cristiano were and are a special duel which will remain forever. They last many years and it is not easy to maintain those levels for such a long time.
‘Our teams were also very demanding: Real Madrid and Barcelona, the two strongest clubs in the world. Competing as equals for so many years is something that will remain forever.
‘The duel between me and Cristiano was very good on a personal level and I think people enjoyed it. The fans of Real, Barca, but in general all football fans, have seen a great show. We hope to give them even more emotions [on Wednesday].’